Fast dissolving drug delivery is rapidly gaining acceptance as an important new drug delivery technology. The dosage form to disintegrate rapidly in the patient's mouth within a minute and can be gulped easily, thus, it offers increased patient compliance and convenience. The purpose of this work is to formulate and evaluate orally disintegrating tablet (ODT) of Lamotrigine with quick disintegration/dispersion in mouth (<30 sec), sufficient mechanical strength to withstand handling during manufacture, packing and distribution with pleasant mouth feel and palatable taste. ODT of lamotrigine is prepared by direct compression method using different proportion of diluents, superdisintegrants, sweeteners, flavors and lubricant. These preparations are evaluated for physical appearance, dimension, crushing strength, weight variation, friability, oral dispersion time, de-aggregation study, wetting time, In vitro dissolution study, drug content, stability study and effect of excipients. This study showed good drug release profile and other parameters were also in acceptable range. Optimized batches DC13 revealed satisfactory results, required for ideal ODT. . This batch was suitable for scale-up and bioequivivalance (BE) study. Summarizing all parameters, it can be concluded that ODT are the better option for improving patient convenience and compliance.
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